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Significant cost reduction Flexibility Less financial pressure For many, the trade-off becomes logical over time

[DOI] [PubMed] [Google Scholar] 31.Mamun A A, Peeters A, Barendregt J

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Plasma samples were spiked with 0.05% aqueous formic acid containing a deuterated internal standard of cotinine, extracted with a solid phase resin, and analyzed using LC-MS/MS via multiple reaction monitoring (MRM) to quantitate cotinine