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[18] The degree to which teens are using e-cigarettes in ways the manufacturers did not intend, such as increasing the nicotine delivery, is unknown, [107] as is the extent to which e-cigarette use may lead to addiction or substance dependence in young people

[40] in acupuncture related studies

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Additionally, nicotine exposure alters brain regions responsible for stress management, learning, and self-control, exacerbating stress and anxiety and impairing an individuals ability to exercise self-control.

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