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tobacco historical significance Beyond Tobacco: A Journey Through the History and Cultural of Herbal Smoking North America's Earliest Smokers May
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Johann Michael Elasser noted the connection between pipe smoking and lip cancer in 1795, and scattered clinical observations accumulated through the nineteenth century, but the scientific case against tobacco was constructed methodically only in the mid-twentieth century
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The duty rose from 2p per pound to 6s 10p, a 40-fold increase, but English demand remained strong despite the high price
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doi:10.1111/j.1467-842X.2002.tb00910.x
