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In smokers, a single dose of the xanthine oxidase inhibitor allopurinol restores the acetylcholine-induced endothelium-dependent relaxation response in forearm arteries to nonsmoker levels but does not affect the endothelium-dependent relaxation response in nonsmokers [73]

Since the 1990s, nicotine has been linked to nearly all GI organ cancers in experimental models employing animals, cell cultures, and clinical data

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And lung cancer is the most common cause of cancer death