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Rivera and his team/colleagues evaluated the skeletal muscle effects of electronic cigarette aerosol, delivered in a manner similar to human vaping, in a mouse model of obesity induced by a high-fat diet

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This indicates that exposure to a stressor leads to the release of CRF which contributes to nicotine-seeking behavior by activating CRF 1 receptors

And the amount of nicotine in many vaping products is much higher than in regular cigarettes

Effects of dopamine receptor D4 variation on alcohol and tobacco use and on novelty seeking: Multivariate linkage and association analysis