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Once that occurs, the rest is history

Lastly, nicotine also has peripheral vasoconstrictive or bronchoconstrictive effects ( Finally, the Amazonian epistemic concepts that play a role in tobacco-based treatments as per our informant are consistent with traditional Amazonian conceptions of healing and sickness in general (e.g., concept of plants with agency, concept of spiritual/energetic factors in pathogenesis and treatment

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The New York Daily News warned that "e-cigarettes could be a gateway to hard drugs." According to Forbes.com health writer Melanie Haiken, the Kandels' research "shows" that "e-cigarettes may be a 'gateway' drug for teenagers." Keep in mind that the Kandels' research pertains to nicotine in general, not e-cigarettes specifically