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As rightly noted, the systemic inflammation index (SII) is a composite measure derived from platelet, neutrophil, and lymphocyte counts, all of which are non-specific markers that can be elevated by a wide range of acute and chronic inflammatory conditions beyond smoking, such as infections, autoimmune diseases, malignancies, and other metabolic syndromes

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When these elements harmonize, they create a one-of-a-kind smoking experience that appeals to both novice and seasoned pipe smokers