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The calcium releaseactivated calcium (CRAC) channels formed by calcium release-activated calcium channel protein (ORAI) 1 and ORAI2 also play essential roles in the non-IgE-dependent activation of MCs within the neuroimmune axis, and they are increasingly being investigated as novel pharmacological targets (170, 171)
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Adults exposed to secondhand smoke have a 25-30% increased risk of heart disease
Paffenbarger RS, Jr, Lee IM, Leung R
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