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Although rare, associations with nonarteritic anterior ischemic optic neuropathy, pancreatitis, medullary thyroid carcinoma, and acute kidney injury (AKI) have been reported, primarily through pharmacovigilance and case-based evidence

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Cigarette smoking leads to upregulation of brain nicotinic acetylcholine receptors (nAChRs), including the common 42* nAChR subtype