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Conclusions on nicotine pharmacology The main effect of nicotine (besides its action on the cholinergic system) is the presynaptic release in the brain of neurotransmitters such as acetylcholine, noradrenaline, dopamine, serotonin, glutamate, GABA and opioid peptides

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Bertone-Johnson ER, Hankinson SE, Johnson SR, Manson JAE (2008) Cigarette smoking and the development of premenstrual syndrome

Once it leaves the brain, it can lead to withdrawal symptoms

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