risk of oral cancer from chewing tobacco and Health risk of oral cancer after
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[125] Nickel was the first wire used because it has the highest coefficient of the common metals

Addiction and dependency Nicotine, a primary ingredient in e-cigarettes, can lead to addiction and dependency, as neuroadaptations can occur with the persistent use of nicotine (e.g., tolerance), withdrawal symptoms can be experienced when intake of nicotine is stopped, and the effects of nicotine that reinforce dependence [51]