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Yet studies, such as this one in Nature , found that the nicotine delivery to the bloodstream from these devices varied, and was still much slower and lower than the concentrations that regular cigarettes give smokers

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Other evidence of the possible irritant and inflammatory effect on cells comes from an in vitro study in which the exposure of tracheobronchial cells to electronic cigarette nicotine-free vapours was related to a concomitant increase in interleukin-6 and interleukin-8 cytokine production with a dose-dependent response and direct evidence of endothelial dysfunction.84 The association with inflammation and endothelial dysfunction is most likely mediated via nitric oxide pathways

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Figures were produced to describe the percentage of smokers intended to quit smoking due to GWLs both among smokers with and without the plan to quit in a year