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Re-thinking Nicotine: A Three-Dimensional Framework for Harm Minimization Nicotine and tobacco products can fit into a three-dimensional conceptual space (Figure 2): (1) harmfulness (x-axis), (2) appeal (z-axis) and (3) dependence (y-axis)

The public must be accurately educated about the relative harms of nicotine-containing products relative to smoking

By 2021, disposables were the most popular type of e-cigarettes, with Puff Bar emerging as the most popular brand

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