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INH is a prodrug that enters the Mtb cytoplasm via passive diffusion, where it inhibits mycolic acid synthesis by targeting the InhA enzyme, an essential catalyst in an early step of the mycolic acid biosynthetic pathway (Mitchison, 1956)

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Also, nicotine interrupts the airway epitheliums barrier function, leading to the release of inflammatory proteins into the systemic circulation and causes multi-organ fibrosis [101]