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Because of the potential loss of nicotine potency after the expiry date, manufacturers discourage people from using patches beyond this time

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Indeed, it has been demonstrated that smoking cessation reduces also endothelin-1, which is a potent vasoconstrictor with proliferative, pro-fibrotic, pro-oxidative and pro-inflammatory properties, maintaining the tone of vascular smooth muscle cells (VSMC) [31]

As well as demonstrate the benefits of vaping as a cessation tool

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