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58 T1DM is an autoimmune disease defined by TCD4+ and TCD8+ lymphocytes invading Langerhans islet cells

Benowitz NL, Schultz KE, Haller CA, Wu AH, Dains KM, Jacob P 3rd

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That said, the sheer volume of nicotine in a large cigar means that even with lower absorption efficiency, substantial amounts still enter the bloodstream over the extended smoking period
