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Premature Aging Smoking is one of the top causes of premature aging

Surgeon General, youths who are heavily exposed to onscreen smoking imagery are approximately two to three times more likely to begin smoking than youths who are less exposed. Aside from its findings, the study also proposed a number of initiatives to limit the amount of smoking exposure in films aimed at teenagers

There is also a need for further development of relevant in vitro models for the toxicological evaluation of endocrine perturbations in the HPG axis (e.g., human Leydig cells), while current OECD Guidelines for the Testing of Chemicals rely on the adreno-carcinoma H295R cell line to assay steroidogenesis 57

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