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Dental procedures, sharp or broken teeth, ill-fitting dentures, and orthodontic appliances can create constant friction and irritation that cause mouth ulcers
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Cognitive neuroscience and neuroimaging, 6(6), 607615
It found that, over time, people who smoked saw their social contact reduce, and they became less socially engaged and more lonely, compared to non-smokers
However, this is unlikely to be a scenario for most people
