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This is partly due to the nicotine content in vapour, which can cause yellow staining, and partly because vapour residue on the walls can attract dust and dirt, which can stick to your interior walls

Through activation of TLR4 pathways, these mediators can increase oxidative stress in the vasculature (153)

Further, evidence suggests that mouth ulcers and constipation are recognised tobacco withdrawal symptoms.42,43 Craving is one of the most often reported symptoms during smoking abstinence and frequently predicts relapse

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