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Use of and exposure to commercial tobacco acts as a risk factor to four of the top five causes of death in Ohio (heart disease, cancer, chronic lower respiratory diseases, and stroke)

Tobacco contains only (S)-nicotine (also called 1-nicotine), which is the most pharmacologically active form

91 These effects are observed shortly after injection with different concentrations of nicotine (from low to high) and can be inhibited with PI3K inhibitor

Cigarette smoking has been shown to be associated with a range of sleep disorders including shorter sleep duration, difficulty initiating and maintaining sleep, snoring and daytime sleepiness

But tobacco companies are keen to promote it as a new revenue stream to replace dwindling cigarette sales