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Description
Counterfeiters clearly spend a great deal of time attempting to exactly copy the look of the cigarette, but they often lace the tobacco with filler, such as sawdust, to reduce production costs

Centers for Disease Control

If nicotine biology turns out to matter, researchers can study it without wrapping it in a delivery system that damages blood vessels, lungs, and cardiovascular health

the participants who smoked more had more frequent migraines

Compared to conventional cigarettes, similar substances with potential carcinogenic or toxic effects are found in aerosol from electronic cigarettes, but in lower concentrations, whereas emitted reactive oxygen radicals appear comparable [24]
