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Dose-dependent benzo(a)pyrene [B(a)P]-DNA adduct levels and persistence in F-344 rats following subchronic dietary exposure to B(a)P

Oxidative stress: Smoking causes oxidative stress, which is when there is an excess of free radicals in the body

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Thus, not only is there less blood flowing to the feet due to the arteries being narrowed, but the blood is also not carrying enough oxygen to the feet anymore

19 From these, 666 underwent brain imaging including high-resolution structural T1-weighted MRI scanning used for cortical thickness estimation (see MRI acquisition section for scanning details)