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10 , 11 The epithelial reaction to antigen exposure begins with the secretion of IL33, TSLP, and IL25, activating innate type 2 lymphoid cells (ILC2) in mucosa and the production of atopic T helper 2 lymphocyte profile cytokines (Th2), with the consequent progression of allergic inflammatory cascade due to its effects on mast cells, macrophages, eosinophils, and CD4 + T lymphocytes

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