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Specifically, Section 907(a)(1)(A) of the Federal Food, Drug, and Cosmetic Act instituted a "special rule for cigarettes." This statute explicitly prohibited any cigarette from containing a "characterizing flavor" other than tobacco or menthol

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Because progesterone modulates FSH in the endocrine feedback loop, the lower progesterone metabolite levels in smokers during the luteal phase are consistent with decreased entrainment of FSH during the lutealfollicular phase transition, leading to the elevations we observed