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We showed that this was the direct result of an effective lobby by ANR, which succeeded in building a broad supportive societal anti-tobacco network, and of its decision to define the problem of tobacco control in terms of protecting youth and aiming for a Smoke-free Generation (issue framing)

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The many uncontrolled variables with e-cigarettes (e.g., nicotine formulation, concentration, number of puffs) makes this challenging

[66] The nicotine levels in the e-cigarette vapor also varies greatly either from puff-to-puff or among devices of the same company