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Traditional methods offer longer-lasting effects and more control overdosing, but can take longer to kick in

Do cigarette taxes make smokers happier?, Cambridge, Massachusetts: National Bureau of Economic Research, 2002

"But the gold standard research studies needed to answer this question (randomized controlled trials) have not been done." Randomized controlled trials allow scientists to directly assess whether one factor causes another

Nicotine products are generally safer than cigarettes Products containing nicotine are only recommended for those people who smoke cigarettes or use other tobacco products and want to quit

The present study complies with the PRISMA guidelines 190 (Supplementary Tables 9 and 10 and Supplementary Information 1.5) and Guidelines for Accurate and Transparent Health Estimates Reporting (GATHER) recommendations 191 (Supplementary Table 11)