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We will summarize the rise and appeal of these products, review nicotines cardiovascular pharmacology, analyze pouch characteristics relevant to risk, evaluate the existing evidence, identify critical knowledge gaps, and discuss the implications for public health policy and prevention

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Our results could be mediated by the increase in body weight, which was evident already at 4 weeks, and thus the remaining study duration was enough to affect HbA1c values which are related to the erythrocyte turnover of around 120 days

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