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A poor-rated meta-analysis that pooled together different SLT-products from 16 global studies reported increased risk of overall mortality (OR = 1.22

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For each brand, we also measured levels of the TSNAs, NNN ( N -nitrosonornicotine), and NNK (4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone) via HPLC-MS, and the nicotine content via GC-FID