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6.3 Smoking 6.3.1 Inhibiting Effect of Smoking on Nicotine Clearance Cigarette smoking itself influences the rate of metabolism of nicotine

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Congress created a special rule for exposure modification orders, allowing FDA to authorize such claims where long-term epidemiological evidence may not yet be available, but the available evidence supports that the product is reasonably likely to reduce morbidity or mortality, substantially reduce exposure to harmful substances, and not mislead consumers into believing that the product has been shown to reduce disease risk unless that has been demonstrated

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