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Heavy passive exposure can sometimes trigger a low-level positive, which is why quantitative testing may use lower cutoffs (e.g., 20 ng/mL in urine) to differentiate passive exposure from active use
Pesticide exposure has been associated with long-term and chronic health effects including respiratory problems, cancer, depression, neurologic deficits, and reproductive health problems

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Promoted by the manufacturers, there are discussions if this means a reduction of health risks for HTP consumers followed by controversies whether HTPs can be seen as part of harm reduction strategies

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