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It develops an emotional dependence of I need this to cope right now and conditions the brain to smoke when faced with stress, anxiety, or other emotional states

doi: 10.1146/annurev.clinpsy.3.022806.091415

Chronic smoking also leads to the formation of atheromatous plaques due to increased expression of matrix metalloproteinases (MMP), particularly MMP-12 and MMP-9 in macrophages, MMP-8 and MMP-9 in endothelial cells, and MMP-2 and MMP-9 in vascular smooth muscle cells (35,36)

We conducted Medline and Cochrane searches for studies measuring HDL-C in subjects while still smoking and later having quit

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