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[DOI] [PMC free article] [PubMed] [Google Scholar] [262].Miller JW, Nadeau MR, Smith J, Smith D, Selhub J, Folate-deficiency-induced homocysteinaemia in rats: disruption of S-adenosylmethionines co-ordinate regulation of homocysteine metabolism, The Biochemical journal, 298 (Pt 2) (1994) 415419

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In a cohort of 494 children followed over one year, 117 developed new dental caries in permanent teeth, corresponding to a caries incidence rate of 0.183 per person-year

The National Institute for Health and Care Excellence looked at the evidence and stated: Six studies evaluated the safety of NRT in patients with cardiac disease and did not find any increased incidence of cardiovascular events or any other adverse events