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In Bray-Curtis distance-based PCoA of smokeless-tobacco-consuming and non-consuming healthy samples, PCo-1 explained 26% variation among healthy samples and significantly separated the two groups (PERMANOVA R 2 = 0.0634, p -value = 0.001, Figure 1D )

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In susceptible subjects, cigarette smoke triggers a complex cascade of inflammation, with oxidative stress, accelerated cellular senescence and aberrant repair processes

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