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All smokers participated in a 12-week smoking cessation treatment during which Varenicline was used to aid cessation

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In 1971, Philip Morris experimented on competitors brands and found that ammonia added at 0.25% concentration created a taste that was milder, more aromatic, sweeter, less harsh, and more like a Marlboro, whereas ammonia added at 0.50% concentration created an off taste.6 RJ Reynolds scientists later hypothesized that ammonia might improve tobacco smoke flavor by reacting with sugars to produce heterocyclic ring compounds known as pyrazines

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