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Some data suggests that bupropion and nicotine replacement therapy (NRT) may improve negative symptoms of schizophrenia, and that individuals on atypical antipsychotic drugs may be more responsive to bupropion than those on traditional antipsychotic medication

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Identifying what a patient has already tried during their attempts to quit nicotine, as well as their mental and physical reactions to it, can help to determine what the next method of quitting can entail.[16] If one is trying to quit, it is important to recognize that the cessation process will require constant effort

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