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Direct Toxic Effects of Cigarette Smoke on Intestinal Milieu/Autoimmunity While there is little doubt, as this review has already demonstrated, that smoking is detrimental to treatment outcomes in IBD based on a multitude of observational data, there are remarkably few studies that have explored the underlying mechanisms of which and how particular constituents of tobacco smoking affect the intestinal milieu and/or relevant immune-inflammatory pathways

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Evidence to support direct effects of H1 receptor antagonism on development of NAFLD is scarce however, H1R antagonism was reported to exacerbate high fat diet induced NAFLD in wild-type mice (Raveendran et al., 2014), suggesting a role of this receptor subtype in the pathogenesis of NAFLD