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Given the role of incentive proximity in the functional organization of behavior systems (Timberlake, 1994

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The pathogenetic factors involved include structural changes in the gut that increase with age, a diet low in fibre and rich in meat, changes in intestinal motility, the concept of enteric neuropathy and an underlying genetic background

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It is evident that a combination of synergistic population-level strategies helped accelerate this decline of cigarette use