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Nicotine addiction was highlighted as a persistent issue, with e-cigarettes perpetuating dependence rather than serving as a smoking cessation tool

Instrumentation LC-MS/MS analyses were carried out with a Thermo Accela UPLC pump and Pal Autosampler interfaced to a Thermo Vantage triple-stage quadrupole mass spectrometer, or with a Thermo/Dionex UltiMate 3000 RS Pump UPLC+ Focused UPLC and CTC/Dionex UltiMate 3000 XRS Open Autosampler interfaced to a Thermo Quantiva triple-stage quadruple mass spectrometer

"Certainly the best way to go is not to do it

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