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Furthermore, current smokers have been shown to have a higher HCC risk (HR = 2.46, 95% CI = 1.773.43) in a dose-dependent manner with the number of cigarettes smoked [104]

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In methamphetamine dependence, results of a 12-week RCT (N=229) using sertraline 100 mg/d vs placebo (+/- contingency management) led the authors to deem sertraline contraindicated . 16 An increased propensity to relapse after completing 6 weeks of treatment in the sertraline groups (13/61) vs placebo (5/68) appeared to relate to sustained craving for methamphetamine