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A Cochrane review of interventions for tobacco use cessation in people in treatment for or recovery from substance use found that offering pharmacotherapy for smoking cessation increased tobacco abstinence (risk ratio (RR) 1.88, 95%CI 1.35 to 2.57), as did combined counselling and offering pharmacotherapy for smoking cessation (RR 1.74,95% CI 1.39 to 2.18) compared with usual care or no intervention

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Another benefit is that the detection of any species within the cigarette can be conducted at a higher sensitivity without any buffering caused by subsequent smoke passage

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The smokeless tobacco consumers had significantly elevated levels of epinephrine in comparison with the non-consumers (Figure 1)