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Medication A doctor may prescribe medications to reduce pain and other symptoms of smokers leg, including: cilostazol (Pletal) to reduce claudication symptoms daily aspirin therapy or clopidogrel (Plavix) to reduce blood clotting statins, such as rosuvastatin (Crestor) or atorvastatin (Lipitor), to reduce cholesterol levels angiotensin converting enzyme inhibitors to lower blood pressure levels medications to manage blood sugar levels, in people with diabetes Angioplasty and vascular surgery If routine changes and medications do not work, a doctor may recommend angioplasty, stenting, or vascular bypass surgery