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cigarette smoke induces cytoplasmic p53 accumulation Dysregulation of immunity by smoking promotes inflammation and cancer: A review Smoking & Cancer | Genetic
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[DOI] [PubMed] [Google Scholar] 2.Sun X., Zhang N., Yin C., Zhu B., Li X

Trends Biochem

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As previously referred, inflammatory pathways can also be activated by UVR-induced ROS or indirectly by DNA or mitochondrial damage, where both keratinocytes and fibroblasts contribute to the inflammatory condition and extracellular matrix degradation

Figure 2.9 The p53 protein directs suicide of cells with DNA damage
