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Abstract Chemical analysis of residues contained in the matrix of stone smoking pipes reveal a substantial direct biomolecular record of ancient tobacco ( Nicotiana ) smoking practices in the North American interior northwest (Plateau), in an area where tobacco was often portrayed as a Euro-Americanintroduced postcontact trade commodity

This system created some of Americas richest families and two of the most prominent were in North Carolinathe Dukes in Durham and the Reynoldses in Winston-Salem

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In vitro RNA-seq-based toxicogenomics assessment shows reduced biological effect of tobacco heating products when compared to cigarette smoke