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Treatment strategies Pharmacotherapies that target the nAChRs, which mediate the reinforcing properties and neurocognitive effects of nicotine in smokers, may have therapeutic effects on neurocogni-tive dysfunction in schizophrenia.7,12 Several promising nAChR agents, including galantamine (an allosteric modulator of central nAChRs), DMXB-A (7-selective agonist), TC-5619 (a selective 42 nAChR agonist), and varenicline (42 partial agonist), have been studied in patients with schizophrenia.31-34 A recent study by Hong and colleagues35 found that varenicline treatment in stable, medication-compliant schizophrenia patients for 8 weeks (1 mg/d) improved sensory gating, startle reactivity, and executive function