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And they illustrate the importance of studying drug effects, and the neurological changes they trigger, in the context of the dynamic processes that characterize adolescent brain development." Rats First Exposed to Nicotine in Adolescence Show Greater Sensitization to Cocaine Than Rats First Exposed as Adults Rats exposed to nicotine in adolescence and then exposed to cocaine were more sensitive to cocaines locomotor stimulating effects than rats first exposed to nicotine as adults