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In common parlance when we say something contains chemicals, it means artificial additives or synthetic compounds and comes with a negative connotation

This Maton 808 was handmade for the stage

[5] Many substances in cigarette smoke, chiefly nicotine, trigger chemical reactions in nerve endings, which heighten heart rate, alertness [6] and reaction time, among other things

Traditional tobacco has been used by American Indian nations for centuries as a medicine with cultural and spiritual importance

Cattle: (Old World) In 1493, Christopher Columbus carried cattle with him on his second voyage
