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In addition to its direct effects on midbrain DA neurons, nicotine also alters DA signaling in the NAc itself 9094

Across all countries, a total of 40,064 respondents aged 18 to 98 (median: 41) completed the survey and provided valid data, i.e., reported sex, age, education and number of household members

Healthline: What You Need to Know About Smoking and Your Brain National Library of Medicine: Short- and Long-Term Consequences of Nicotine Exposure during Adolescence for Prefrontal Cortex Neuronal Network Function Smarmore Castle: Coffee and Cigarettes Side Effects A Really Bad Combination Kwit: Is it a Good Idea to Mix Nicotine and Caffeine Quora: Why Do Coffee and Cigarettes Taste So Good

however, most quit attempts fail, and about 80% will go on to smoke into adulthood