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First-time users or low-tolerance smokers and vapers are especially prone to it

In large doses, it activates the hypothalamicpituitaryadrenal axis, similar to stress response, and in regular use causes hypothyroidism.[9,11] Higher serum T3 and lower T4 levels were seen in cases when compared to controls in the present study

These findings align with a VBM meta-analysis demonstrating reduced gray matter volume in the bilateral rolandic operculum, the bilateral prefrontal cortex, and the bilateral insula in addiction-related disorders compared to healthy controls [39]

I can't figure it out using the diagram on the box

Prevalence, attitude, misconception, and predictors of electronic cigarette among King Khalid University students, Abha, Aseer region, Saudi Arabia