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Neither varenicline nor nicotine replacement had been shown to decrease drinking rates in smokers before, so it was unclear why the study participants reduced their drinking during the study

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Lung cancer, including both non-small cell lung carcinoma and small cell lung carcinoma

In addition, nicotine has a cascading effect on central neurotransmission also resulting in the release of norepinephrine and histamine as well as GABA and glutamate (28, 29)