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Nevertheless, although nicotine and leptin elicit similar responses (whether at the level of excitability or transcriptional regulation) in certain hypothalamic, vagal afferent and sympathetic efferent neurons, their sites of action are often distinct

FDA will ensure that its review of cigarette plans will be completed no later than 6 months after receipt of an adequate plan from persons who work in good faith with FDA to complete its review (e.g., persons should work diligently with FDA and be responsive by submitting any requested information in a timely manner)

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The most important takeaway is that use is almost exclusively among people who already smoke or used to smoke, cementing its role as a product for switching, not starting
